Pharmacopoeial impurityRivastigmine EP Impurity DCat. No. P-R073-003CAS 415973-05-6
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Active ingredient · Rivastigmine family
Pharmaceutical analytical standardRivastigmine Hydrogen Tartrate
Synonyms: Rivastigmine Tartrate, Rivastach, Exelon MR, Exelon TDS, Nimvastid
- Cat. No.
- P-R073-001
- CAS
- 129101-54-8
- Alternative CAS
- 123441-03-2 (free base)
- 406174-29-6 (alternative CAS, same compound)
- Formula
- C14H22N2O2·C4H6O6
- Molecular weight
- 400.43 g/mol
- Category
- Active ingredient (API)
A cholinesterase inhibitor, a semi-synthetic derivative of physostigmine, that raises acetylcholine in the brain: in use since 1997 for mild to moderate dementia in Alzheimer's disease and, later, in Parkinson's disease.
Did you know?In 2006 it became the first medicine approved for dementia associated with Parkinson's disease, and in 2007, as a transdermal patch, the first dementia treatment applied to the skin.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
Pharmacopoeial standards available
The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.
- Rivastigmine Hydrogen TartrateBP 1257
- Rivastigmine Impurity MixtureBP 1258
- Rivastigmine for system suitability CRSEP Y0001485
- Rivastigmine hydrogen tartrate CRSEP Y0001516
More products in the Rivastigmine family
Pharmacopoeial impurityRivastigmine EP Impurity DCat. No. P-R073-003CAS 415973-05-6
Pharmacopoeial impurity(R)-Rivastigmine D-TartrateCat. No. P-R073-004
Pharmacopoeial impurityRivastigmine EP Impurity ACat. No. P-R073-005CAS 139306-10-8
Pharmacopoeial impurityRivastigmine EP Impurity A L-TartrateCat. No. P-R073-006
Pharmacopoeial impurityRivastigmine EP Impurity B (as Racemate Hydrochloride)Cat. No. P-R073-007CAS 105601-13-6
Pharmacopoeial impurityRivastigmine EP Impurity BCat. No. P-R073-008CAS 1230021-28-9
Pharmacopoeial impurityRivastigmine EP Impurity B L-TartrateCat. No. P-R073-010
Pharmacopoeial impurityRivastigmine EP Impurity CCat. No. P-R073-011CAS 855300-09-3Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.