Active ingredientRosuvastatin CalciumCat. No. P-R088-001CAS 147098-20-2
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Pharmacopoeial impurity · Rosuvastatin family
Pharmaceutical analytical standardRosuvastatin EP Impurity A t-Butyl Ester
Synonyms: S-Desmethyl-S-(2-hydroxy-2-methylpropyl) Rosuvastatin tert-Butyl Ester
- Cat. No.
- P-R088-008
- CAS
- 1714147-49-5
- Alternative CAS
- N/A
- Formula
- C29H42FN3O7S
- Molecular weight
- 595.73 g/mol
- Category
- Pharmacopoeial impurity (EP/USP)
Family: Rosuvastatin
A statin developed in Japan in the 1990s and approved in the early 2000s to lower LDL cholesterol. It blocks HMG-CoA reductase, the enzyme the liver uses to make cholesterol.
Did you know?The statin story starts with a mould: in the 1970s the Japanese biochemist Akira Endo isolated the first one, mevastatin, from a Penicillium fungus.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Rosuvastatin family
Active ingredientRosuvastatin CalciumCat. No. P-R088-001CAS 147098-20-2
ImpurityRosuvastatin Sodium Salt (Mixture of Diastereomers)Cat. No. P-R088-002CAS 1007871-86-4
Active ingredientRosuvastatin Sodium Salt (3R,5S)Cat. No. P-R088-003CAS 147098-18-8
Pharmacopoeial impurityRosuvastatin EP Impurity GCat. No. P-R088-004CAS 1242184-42-4
Pharmacopoeial impurityRosuvastatin EP Impurity A Calcium SaltCat. No. P-R088-006CAS 1714147-47-3
Pharmacopoeial impurityRosuvastatin EP Impurity A Sodium SaltCat. No. P-R088-007CAS 1714147-50-8
Pharmacopoeial impurityRosuvastatin EP Impurity B Calcium SaltCat. No. P-R088-009
Pharmacopoeial impurityRosuvastatin EP Impurity B Sodium SaltCat. No. P-R088-010Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.