Active ingredientSunitinibCat. No. P-S133-001CAS 557795-19-4
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Impurity or related compound · Sunitinib family
Pharmaceutical analytical standardSunitinib Impurity 31
Synonyms: 4-Ethoxycarbonyl-3,5-dimethyl-1-nitrosopyrrole-2-carboxylic acid
- Cat. No.
- P-S133-059
- CAS
- N/A
- Alternative CAS
- N/A
- Formula
- C10H12N2O5
- Molecular weight
- 240.22 g/mol
- Category
- Impurity or related compound
Family: Sunitinib
A multitargeted tyrosine kinase inhibitor (VEGFR, PDGFR, KIT) that slows tumour growth and the formation of the blood vessels feeding it. Approved in 2006, it is used in advanced kidney cancer and gastrointestinal stromal tumours (GIST).
Did you know?It was the first cancer drug approved by the FDA for two different tumours at the same time. It was designed to mimic ATP: it occupies the site where kinases bind this energy molecule.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Sunitinib family
Active ingredientSunitinibCat. No. P-S133-001CAS 557795-19-4
Active ingredientSunitinib MalateCat. No. P-S133-002CAS 341031-54-7
MetaboliteSunitinib N-GlucuronideCat. No. P-S133-003
Isotopically labelledN-Desethyl Sunitinib-d5Cat. No. P-S133-004CAS 1217247-62-5
Isotopically labelledSunitinib-d10Cat. No. P-S133-005CAS 1126721-82-1
Isotopically labelledSunitinib-d4Cat. No. P-S133-006CAS 1126721-79-6
NitrosamineN-Nitroso N-Desethyl SunitinibCat. No. P-S133-007
NitrosamineN-Nitroso Sunitinib Impurity 1Cat. No. P-S133-008Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.