Isotopically labelledTeriflunomide-D4Cat. No. P-T062-002CAS 1185240-22-5
Drag to rotate
Impurity or related compound · Teriflunomide family
Pharmaceutical analytical standardTeriflunomide Impurity 1
Synonyms: 2-Oxo-2-[[4-(trifluoromethyl)phenyl]amino]acetic Acid, 2-oxo-2-[4-(trifluoromethyl)anilino]acetic acid
- Cat. No.
- P-T062-004
- CAS
- 69066-42-8
- Alternative CAS
- N/A
- Formula
- C9H6F3NO3
- Molecular weight
- 233.14 g/mol
- Category
- Impurity or related compound
Family: Teriflunomide
An immunomodulator that blocks the enzyme dihydroorotate dehydrogenase, slowing the de novo synthesis of pyrimidines, building blocks of DNA and RNA: it was approved in the US in 2012 and in the European Union in 2013 for multiple sclerosis.
Did you know?It is the main active metabolite of leflunomide, an older drug: about 70% of leflunomide turns into teriflunomide in the body, simply by the opening of an isoxazole ring.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Teriflunomide family
Isotopically labelledTeriflunomide-D4Cat. No. P-T062-002CAS 1185240-22-5
NitrosamineN-Nitroso TeriflunomideCat. No. P-T062-003
ImpurityTeriflunomide Impurity 2Cat. No. P-T062-005CAS 3788-94-1
ImpurityTeriflunomide Impurity 3Cat. No. P-T062-006
ImpurityTeriflunomide Lactose Adduct 1Cat. No. P-T062-007
ImpurityTeriflunomide Lactose Adduct 2Cat. No. P-T062-008
ImpurityTeriflunomide-E IsomerCat. No. P-T062-009CAS 214782-56-6Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.