Active ingredientTezacaftorCat. No. P-T080-001CAS 1152311-62-0
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Stable isotope labelled · Tezacaftor family
Pharmaceutical analytical standardTezacaftor-d4
Synonyms: VX-661-d4
- Cat. No.
- P-T080-004
- CAS
- 1961280-24-9
- Alternative CAS
- 1152311-62-0 (unlabelled form)
- Formula
- C26H23D4F3N2O6
- Molecular weight
- 524.53 g/mol
- Category
- Stable isotope labelled
Family: Tezacaftor
A CFTR protein modulator for cystic fibrosis, approved in 2018 in the United States and the European Union together with ivacaftor, and since 2019 (in the US) also in a triple combination with elexacaftor and ivacaftor.
Did you know?It is a 'corrector': it helps the CFTR protein altered by the F508del mutation fold into the right shape and reach the cell surface, where it can work.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Tezacaftor family
Active ingredientTezacaftorCat. No. P-T080-001CAS 1152311-62-0
MetaboliteTezacaftor Metabolite 1 (Mixture of Diastereomers)Cat. No. P-T080-002CAS 1432656-97-7
Isotopically labelled(S)-Tezacaftor-d4Cat. No. P-T080-003
Impurity(S)-TezacaftorCat. No. P-T080-005CAS 1152311-99-3
ImpurityTezacaftor Impurity 1Cat. No. P-T080-006CAS 862574-88-7
ImpurityTezampanelCat. No. P-T080-007CAS 154652-83-2
ImpurityTezosentanCat. No. P-T080-008CAS 180384-57-0Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.