Impurity1-MethylaziridineCat. No. P-T098-002CAS 1072-44-2
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Active ingredient · Thiotepa family
Pharmaceutical analytical standardThiotepa
Synonyms: tris(aziridin-1-yl)-sulfanylidene-lambda5-phosphane, Thiotepum, Triethylenethiophosphoramide, Thiophosphamide, Thioplex, Tespamin, Tespamine, Tifosyl, Girostan, Thiofozil, Stepa, Oncotiotepa, TESPA, Thiotef, Tepadina, Ledertepa, Tiotepa, Tris(1-aziridinyl)phosphine sulfide, Thiotriethylenephosphoramide, NSC 6396, TIO TEF, Tepylute, Thiophosphamidum, Tris(ethylenimino)thiophosphate, N,N',N''-Triethylenethiophosphoramide, Triaziridinylphosphine sulfide, Triethylenethiophosphorotriamide, Phosphorothioic acid triethylenetriamide, Tri(ethyleneimino)thiophosphoramide, Tris(1-aziridinyl)phosphine sulphide, N,N',N''-Triethylenethiophosphamide, N,N',N''-Triethylenephosphorothioic triamide, N,N',N''-Tri-1,2-ethanediylthiophosphoramide, Aziridine,1,1',1''-phosphinothioylidynetris-, Tris(aziridin-1-yl)-lambda5-phosphanethione, Tris(aziridin-1-yl)-sulfanylidenephosphorane, Tris(aziridin-1-yl)-$l^(5)-phosphanethione, Thiofosfamide, TSPA, Tri(aziridin-1-yl)phosphine sulfide, Tiofosfamid, Oncotepa, Tiofosyl, Tiofozil, Oncothio-tepa, Thio-Tep, Thio-tepa S, Phosphine sulfide, tris(1-aziridinyl)-, Tri(1-aziridinyl)phosphine sulfide, Tris(aziridinyl)phosphine sulfide, N,N',N''-Triethylenethiophosphortriamide, Thioplex (TN) (Immunex), Thiophosphoramide, N,N',N''-tri-1,2-ethanediyl-, N,N',N''-Tri-1,2-ethanediylphosphorothioic triamide, Phosphorothioic triamide, N,N',N''-tri-1,2-ethanediyl-, Phosphorothioic triamide, N,N',N''-triethylene-, Tespam, Rethio, Thiophosphoramide, N,N',N''-triethylene-, N,N''-Triethylenethiophosphamide, N,N''-Triethylenethiophosphoramide, Pharmakon1600-01503324, NSC 758455, Thiophosphoramide,N',N'' -triethylene-, N,N',N'''-Triethylenethiophosphhoramide, Phosphorothioic tri(ethyleneamide), N,N''-Triethylenephosphorothioic triamide, Aziridine,1',1''-phosphinothioylidynetris-, N,N''-Tri-1,2-ethanediylthiophosphoramide, Phosphorothioic triamide,N',N''-triethylene, Tris(aziridin-1-yl)-thioxo-lambda5-phosphane, Thiophosphoramide,N',N''-tri-1,2-ethanediyl-, N,N''-Tri-1,2-ethanediylphosphorothioic triamide, Phosphorothioic triamide,N',N''-tri-1,2-ethanediyl-
- Cat. No.
- P-T098-001
- CAS
- 52-24-4
- Alternative CAS
- 1631739-26-8 (alternative CAS, same compound)
- Formula
- C6H12N3PS
- Molecular weight
- 189.22 g/mol
- Category
- Active ingredient (API)
An alkylating agent and one of the oldest chemotherapy drugs, approved in the United States in 1959: it is also used in conditioning regimens that prepare patients for blood stem cell transplantation.
Did you know?Its name is short for thiotriethylenephosphoramide: the molecule carries three aziridine rings, small and highly reactive triangles that bind to the DNA of cancer cells and stop it from being copied.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
Pharmacopoeial standards available
The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.
- ThiotepaBP 331
More products in the Thiotepa family
Impurity1-MethylaziridineCat. No. P-T098-002CAS 1072-44-2
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ImpurityThiotepa Impurity 1Cat. No. P-T098-004CAS 62679-38-3
ImpurityN,N',N-triethylenephosphoramideCat. No. P-T098-005CAS 545-55-1
ImpurityThiotepa Impurity 2Cat. No. P-T098-006CAS 121258-29-5
ImpurityN-Chloro Ethyl ThioTEPACat. No. P-T098-007CAS 90877-51-3
ImpurityThiotepa Impurity 3Cat. No. P-T098-010
ImpurityThiotepa Impurity 4Cat. No. P-T098-011Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.