Active ingredientTimololCat. No. P-T123-001CAS 26839-75-8
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Pharmacopoeial impurity · Timolol family
Pharmaceutical analytical standardTimolol EP Impurity I
Synonyms: Timolol Impurity N8, Desisobutyl-n-ethyl timolol, (rs)-, Desisobutyl-n-ethyl timolol, (+/-)-
- Cat. No.
- P-T123-020
- CAS
- 2469037-77-0
- Alternative CAS
- N/A
- Formula
- C11H20N4O3S
- Molecular weight
- 288.37 g/mol
- Category
- Pharmacopoeial impurity (EP/USP)
Family: Timolol
A non-selective beta blocker patented in 1968: it is also taken by mouth for high blood pressure, but is best known as eye drops that lower the pressure inside the eye in glaucoma.
Did you know?In 1978 it became the first beta blocker approved in the United States for application directly to the eye, as drops, to treat glaucoma.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Timolol family
Active ingredientTimololCat. No. P-T123-001CAS 26839-75-8
Active ingredientTimolol HemihydrateCat. No. P-T123-002CAS 91524-16-2
Active ingredientTimolol MaleateCat. No. P-T123-003CAS 26921-17-5
Pharmacopoeial impurity(S)-Timolol EP Impurity CCat. No. P-T123-004CAS 1391068-18-0
Pharmacopoeial impurity(S)-Timolol EP Impurity C MaleateCat. No. P-T123-005
Pharmacopoeial impurityTimolol EP Impurity ACat. No. P-T123-006CAS 26839-76-9
Pharmacopoeial impurityTimolol EP Impurity A MaleateCat. No. P-T123-007CAS 26839-77-0
Pharmacopoeial impurityTimolol EP Impurity B (S-Isomer)Cat. No. P-T123-008CAS 158636-96-5Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.