Active ingredientVarespladibCat. No. P-V020-001CAS 172732-68-2
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Impurity or related compound · Varespladib family
Pharmaceutical analytical standardVarespladib Methyl
Synonyms: methyl 2-(1-benzyl-2-ethyl-3-oxamoylindol-4-yl)oxyacetate, Varespladib methyl ester, Acetic acid, ((3-(aminooxoacetyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl)oxy)-, methyl ester, Methyl varespladib
- Cat. No.
- P-V020-004
- CAS
- 172733-08-3
- Alternative CAS
- N/A
- Formula
- C22H22N2O5
- Molecular weight
- 394.43 g/mol
- Category
- Impurity or related compound
Family: Varespladib
An inhibitor of secretory phospholipases A2 created for inflammatory and cardiovascular diseases, whose development in cardiology stopped in 2012 for insufficient efficacy; since 2016 it has been studied as a possible antidote to snake venom.
Did you know?It also exists in an oral form, varespladib methyl, which could be taken straight after a bite, before reaching hospital; in 2019 the FDA granted it orphan drug designation for this use.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Varespladib family
Active ingredientVarespladibCat. No. P-V020-001CAS 172732-68-2
Isotopically labelledVarespladib-d5Cat. No. P-V020-002
Isotopically labelledVarespladib-d7Cat. No. P-V020-003CAS 1360701-64-9Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.