Active ingredientYohimbine HydrochlorideCat. No. P-Y001-001CAS 65-19-0
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Pharmacopoeial impurity · Yohimbine family
Pharmaceutical analytical standardYohimbine EP Impurity D(Pseudoyohimbine)
Synonyms: Yohimbine EP Impurity D, Pseudoyohimbine, NSC 72116, Methyl (3beta,16alpha)-17-hydroxyyohimban-16-carboxylate, Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, (3beta,16alpha)-, Methyl (3beta,16alpha,17alpha)-17-hydroxyyohimban-16-carboxylate, Pseudo-yohimbine (ep impurity), Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, (3beta,16alpha,17alpha)-, Methyl (1R,15R,18S,19R,20S)-18-hydroxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate, Psi-yohimbine, Pseudoyohimbin, Yohimban-16-carboxylic acid, methyl ester, (3beta,16alpha,17alpha)-
- Cat. No.
- P-Y001-004
- CAS
- 84-37-7
- Alternative CAS
- 6363-59-3 (hydrochloride)
- Formula
- C21H26N2O3
- Molecular weight
- 354.45 g/mol
- Category
- Pharmacopoeial impurity (EP/USP)
Family: Yohimbine
An indole alkaloid extracted from the bark of the yohimbe, a tree of western and central Africa, first isolated in 1896 by Adolph Spiegel. It blocks alpha-2 adrenergic receptors and in veterinary medicine is used to reverse xylazine sedation in dogs and deer.
Did you know?Its chemical structure was only worked out in 1943 by Bernhard Witkop, almost half a century after its isolation; the first total synthesis, in 23 steps, came in 1958 from Eugene van Tamelen.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Yohimbine family
Active ingredientYohimbine HydrochlorideCat. No. P-Y001-001CAS 65-19-0
Pharmacopoeial impurityYohimbine EP Impurity ACat. No. P-Y001-002CAS 549-84-8
Pharmacopoeial impurityYohimbine EP Impurity CCat. No. P-Y001-003CAS 483-10-3
Pharmacopoeial impurityYohimbine EP Impurity E(Dihydrocorynantheine)Cat. No. P-Y001-005CAS 50439-68-4
Isotopically labelledYohimbine-13C-d3Cat. No. P-Y001-006CAS 1261254-59-4
Isotopically labelledYohimbine-d3Cat. No. P-Y001-007CAS 133146-00-6
ImpurityRauwolscine HClCat. No. P-Y001-008CAS 6211-32-1
ImpurityYohimbine beta-N-OxideCat. No. P-Y001-009CAS 70617-29-7Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.