Active ingredient · Biotin family

Pharmaceutical analytical standard

Biotin

Synonyms: Vitamin H, Vitamin B7, Bioepiderm, Coenzyme R, Bios II, Factor S, Injacom H, Vitamin Bw, Ritatin, Factor S (vitamin), cis-Hexahydro-2-oxo-1H-thieno(3,4)imidazole-4-valeric acid, cis-Tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid, NSC 63865, Hexahydro-2-oxo-1H-thieno(3,4-d)imidazole-4-pentanoic acid, Biotitum, cis-(+)-Tetrahydro-2-oxothieno(3,4)imidazoline-4-valeric acid, Beard, Biotn, Hair, Roemary mint, Hairq-plus, Casotr Oil, Hair Strengthens, Hiar Growth, Bonogen Activator, Tk-nax, Vitamin Essentaial, Spai-sons Procapell, Biotn Topical Serum, DRUGGIST Bar, SUBIR, Spai-sons Prolac-vit, Subir eyelash, Twinkle essence, Biona-vit, DRUGGIST Hair Serum, Gze hair pomade, Reactivate Hair Follicles, ExoSCRT Scalp Care HRLV, Hairjoy eyebrow signature, Hairjoy eyelash signature, Bonogen Activator Hair Loss Treatment, Multi-Peptide Serum for Hair Density, Tfmise hair regrowth treatment, Rosemary Mint Blednd Scalp Hair Strengthening Oil, CVC Rosemary Mint Blend Scalp Hiar Strengthening Oil, DRUGGIST Rosemary Mint Belend Scalp Hiar Strengthening Oil, Biodermatin, Meribin, Lutavit H2, Rovimix H 2, Hexahydro-2-oxo-1H-thieno(3,4-d)imidazole-4-pentanoic acid, (3aS-(3aalpha,4beta,6aalpha))-, Deacura, Gabunat, Rombellin, Biokur, Bios H, Hexahydro-2-oxo-1H-thieno(3,4-d)imidazole-4-pentanoate

Cat. No.: P-B084-001
CAS: 58-85-5
Alternative CAS: 56846-45-8 (alternative CAS, same compound)
Formula: C₁₀H₁₆N₂O₃S
Molecular weight: 244.31 g/mol
Category: Active ingredient (API)

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Characterisation level Level 1 Mass balanceFor small molecules, identity is confirmed by IR, MS, 1H-NMR and 13C-NMR, purity by HPLC (min. 95%) and assay by mass balance (min. 90%); for peptides and similar molecules, identity is confirmed by mass spectrometry (ESI-MS and MALDI-TOF) and IR, purity by HPLC (min. 95%) and assay by mass balance, reported for information only.* Level 2 Mass balance + qNMRFor small molecules, in addition to the Level 1 analyses, the assay is verified by qNMR, an orthogonal method independent of chromatography; for peptides and similar molecules, Level 2 is not available. Analytical documentation supporting qualification as an in-house primary standard under ICH Q7 (§11.17-11.18).

* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.

Quantity

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We reply within 24 hours with a quote and availability. CoA and SDS with every lot.

A water-soluble B vitamin (B7, also called vitamin H from the German Haut, skin): it is the prosthetic group of the carboxylases, key enzymes in the metabolism of fats, sugars and amino acids.

Did you know?In 1936 Fritz Kögl and Benno Tönnis first isolated just 1.1 mg of it from 250 kg of dried egg yolk. Avidin in raw egg white, on the other hand, binds it and blocks its absorption.

The two levels compared

	Level 1 Mass balance	Level 2 Mass balance + qNMR
Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR)	✓	✓
HPLC purity (min. 95%)	✓	✓
Content by mass balance (min. 90%; peptides: for information only)*	✓	✓
Content verified by qNMR (small molecules only)	·	✓
Suitable to qualify it as an in-house primary standard (ICH Q7)	·	✓

What you receive

The analytical standard

Shipped under controlled temperature when the molecule requires it.

Certificate of analysis (CoA)

For every lot: identity, purity and assay, with the supporting spectra and chromatograms.

Safety data sheet (SDS)

Sent with every order.

Tracked shipment

Follow your shipment live, from our warehouse to your lab.

Pharmacopoeial standards available

The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.

Biotin CRSEP B1116000
Biotin for system suitability CRSEP Y0001978

More products in the Biotin family

Pharmacopoeial impurityBiotin EP Impurity ACat. No. P-B084-002CAS 1163708-46-0

Pharmacopoeial impurityBiotin EP Impurity BCat. No. P-B084-003CAS 57671-79-1

Pharmacopoeial impurityBiotin EP Impurity CCat. No. P-B084-004CAS 22342-46-7

ImpurityBiotin Impurity 13Cat. No. P-B084-005CAS 412308-26-0

Pharmacopoeial impurityBiotin EP Impurity D (Mixture of Diastereomers)Cat. No. P-B084-007CAS 415725-35-8

Pharmacopoeial impurityBiotin EP Impurity E (Mixture of Isomers)Cat. No. P-B084-008

Pharmacopoeial impurityBiotin EP Impurity FCat. No. P-B084-010CAS 101469-35-6

Pharmacopoeial impurityBiotin EP Impurity G Bromide SaltCat. No. P-B084-011CAS 33719-11-8

See all 35 products in the family

Frequently asked questions

Is mass balance always performed?

Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.

Can I ask for a different quantity?

Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.

Which level should I choose?

Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.

When will I get the quote?

Within 24 working hours, with price, availability and delivery time.

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