Active ingredientCaffeine CitrateCat. No. P-C006-002CAS 69-22-7
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Active ingredient · Caffeine family
Pharmaceutical analytical standardCaffeine
Synonyms: 1,3,7-trimethylpurine-2,6-dione, Guaranine, Methyltheobromine, Theine, Thein, Cafeina, Cafipel, Koffein, Mateina, Alert-pep, Coffeine, Refresh'n, Caffedrine, Vivarin, Stim, No-Doz, Cafamil, Cafecon, Caffine, Dexitac, Nodaca, Eldiatric C, Durvitan, Hycomine, Organex, Nix Nap, Coffeinum, Coffein, Tirend, Tri-Aqua, Kofein, Methylxanthine theophylline, Teina, Quick Pep, FEMA No. 2224, Cafeine, NSC 5036, Zanthine, Awake, NoSnooze, Allertness Aid, Diurex Ultimate, Trimethylxanthine, Uplift Chewable, Alertness Aid, Diurex Ultra, Yeast-vite, Conrx Alert, Pro-plus, Sprayable Energy, Stay Awake, Alert Aid, Hair Care, Nano Ppc, Diurex Water Pills, Topcare Stay Awake, Alert Alertness Aid, NoDoz Alertness Aid, Sohmed Alertness Aid, Awake Maximum Strength, Diurex Water Pills XPL, Jet Alert Double Strength, Jet Alert Regular Strength, Stay Awake Maximum Strength, Topcare Stay Awake Maximum Strength, GROWTH Hair Serum Serum Capillaire, NoDoz Alertness Aid Maximum Strength, Valumeds Maximum Strength Stay Awake, Phensal, Synalgos, Theophylline, 7-methyl, DHCplus, Miudol, Theobromine, 1-methyl-, Propoxyphene Compound 65, Xanthine, 1,3,7-trimethyl, Theophylline Me, Theobromine Me, Anacin, Anacin Maximum Strength, Caffenium, Monomethyl derivative of Theophylline, Metilteobromina, Kafeina, Trimetilksantina, Respia, Xanthine,3,7-trimethyl, Dimenhydrinate impurity c, Pharmakon1600-01500155
- Cat. No.
- P-C006-001
- CAS
- 58-08-2
- Alternative CAS
- 5892-18-2 (hydrochloride)
- 5743-18-0 (hydrobromide)
- 65116-85-0 (sulfate)
- 60402-91-7 (hydroiodide sodium salt)
- 5743-16-8 (acetate)
- 5743-12-4 (hydrate)
- 17135-90-9 (hydroiodide)
- 69-22-7 (citrate)
- 114303-55-8 (alternative CAS, same compound)
- Formula
- C8H10N4O2
- Molecular weight
- 194.19 g/mol
- Category
- Active ingredient (API)
A methylxanthine alkaloid found in coffee, tea, cocoa and guarana: it stimulates the nervous system by blocking adenosine receptors and is also used in medicine, for example against apnoea in premature babies.
Did you know?It was isolated in 1819 by the German chemist Friedlieb Ferdinand Runge at the suggestion of Goethe, who had given him a box of coffee beans to analyse.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
Pharmacopoeial standards available
The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.
- CaffeineBP 766
- Caffeine CRSEP C0100000
- Caffeine for system suitability CRSEP Y0000787
More products in the Caffeine family
Active ingredientCaffeine CitrateCat. No. P-C006-002CAS 69-22-7
Pharmacopoeial impurityCaffeine EP Impurity CCat. No. P-C006-003CAS 519-32-4
Pharmacopoeial impurityCaffeine EP Impurity ECat. No. P-C006-004CAS 209725-34-8
Pharmacopoeial impurityCaffeine EP Impurity E HClCat. No. P-C006-005CAS 107605-95-8
Pharmacopoeial impurityCaffeine EP Impurity FCat. No. P-C006-006CAS 611-59-6
Isotopically labelledCaffeine-(3-methyl-13C)Cat. No. P-C006-008CAS 202282-98-2
Isotopically labelledCaffeine-13C3Cat. No. P-C006-009CAS 78072-66-9
Isotopically labelledCaffeine-d3Cat. No. P-C006-010CAS 26351-04-2Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.