Nitrosamine1,1,3-Tris(2-chloroethyl)-3-nitrosoureaCat. No. P-C057-004CAS 69113-01-5
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Active ingredient · Carmustine family
Pharmaceutical analytical standardCarmustine
Synonyms: 1,3-bis(2-chloroethyl)-1-nitrosourea, BCNU, Nitrumon, Carmubris, BiCNU, Becenun, Bischloroethyl nitrosourea, Bischlorethylnitrosurea, n,n'-bis(2-chloroethyl)-n-nitrosourea, Bischlorethylnitrosourea, Becenum, Urea, N,N'-bis(2-chloroethyl)-N-nitroso-, FIVB, Camustine, Carustine, Urea, 1,3-bis(2-chloroethyl)-1-nitroso-, Nitrourean, Bis-Chloronitrosourea, Gliadel, Bis(2-chloroethyl)nitrosourea, Bis-N,N'-(chloroethyl)nitrosourea, Gliadel Wafer, Bis(2-chloroethyl)1-nitrosourea, Gliadel (MGI Pharm), Urea,3-bis(2-chloroethyl)-1-nitroso-, Urea,N'-bis(2-chloroethyl)-N-nitroso-
- Cat. No.
- P-C057-001
- CAS
- 154-93-8
- Alternative CAS
- N/A
- Formula
- C5H9Cl2N3O2
- Molecular weight
- 214.05 g/mol
- Category
- Active ingredient (API)
An alkylating agent of the nitrosourea family, developed in the 1960s within the US National Cancer Institute's anticancer programme and approved in 1977: it is used for brain tumours, lymphomas and multiple myeloma.
Did you know?Since 1996 it has also come as biodegradable polymer wafers, devised by Henry Brem and Robert Langer, which the neurosurgeon leaves in the cavity after removing the tumour: the drug is released slowly right where it is needed.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
Pharmacopoeial standards available
The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.
- Carmustine CRSEP Y0002128
More products in the Carmustine family
Nitrosamine1,1,3-Tris(2-chloroethyl)-3-nitrosoureaCat. No. P-C057-004CAS 69113-01-5Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.