Pharmacopoeial impurityClarithromycin EP Impurity ACat. No. P-C181-002CAS 124412-58-4
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Active ingredient · Clarithromycin family
Pharmaceutical analytical standardClarithromycin
Synonyms: Biaxin, Klaricid, Erythromycin, 6-O-methyl-, Macladin, Klacid, Veclam, Zeclar, Mavid, Naxy, Claritromicina, Cyllind, Biaxin XL, Clarosip, Klaricid XL, NSC 758704, Klaricid adult, Klaricid paed, Mycifor xl, Xetinin xl, Clarie xl, Febzin xl, Biaxin Xl Pac, Klaricid i.v., Klaricid 500, Clathromycin, Bicrolid, Clarith, Kofron, Infex, Abbotic, Astromen, Clacine, Clambiotic, Claribid, Claricide, Heliclar, Klaciped, Mabicrol, Clacee, Cyllid, Klarid, Klarin, Maclar, Helas, Adel, Biaxin filmtab, Klax, Biaxin HP, Biaxin xl filmtab, Klaricid Pediatric, Klaricid H.P., Resclar, O(6)-methylerythromycin
- Cat. No.
- P-C181-001
- CAS
- 81103-11-9
- Alternative CAS
- 848130-51-8 (citrate)
- Formula
- C38H69NO13
- Molecular weight
- 747.96 g/mol
- Category
- Active ingredient (API)
A semi-synthetic macrolide antibiotic derived from erythromycin, developed in Japan and on the market since 1991; it is used for respiratory infections and, in combination, to eradicate Helicobacter pylori.
Did you know?It comes from a small change: a methyl group on the hydroxyl at position 6 stops erythromycin from breaking down in stomach acid, making it more stable when taken by mouth.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
Pharmacopoeial standards available
The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.
- ClarithromycinBP 833
- Clarithromycin CRSEP Y0000320
- Clarithromycin for peak identification CRSEP Y0000321
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Pharmacopoeial impurityClarithromycin EP Impurity CCat. No. P-C181-005CAS 127253-06-9
Pharmacopoeial impurityClarithromycin EP Impurity DCat. No. P-C181-006CAS 101666-68-6
Pharmacopoeial impurityClarithromycin EP Impurity ECat. No. P-C181-007CAS 81103-14-2
Pharmacopoeial impurityClarithromycin EP Impurity FCat. No. P-C181-008CAS 128940-83-0
Pharmacopoeial impurityClarithromycin EP Impurity G (Mixture of Z and E Isomers)Cat. No. P-C181-009CAS 107216-09-1Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.